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I have now sequenced my own genome 5 times with an Oxford Nanopore Technologies MinION . This means collecting them from a swab, prepping them for sequencing, running them through a sequencer, then doing analysis over them.

Cheek cells are easily accessible and replenish pretty quickly. They are not used for cancer diagnosis, inflammation, or what genes are being activated in other parts of the body (like if you have hives on your chest and want to test what genes are being expressed in the cells that are inflamed), since you would want to collect the cells having problems and compare them against other normal versions of those cells.

To sequence the cells, I bought lab materials and consumables to sequence my own genome at home. It took me about two months to get everything together to do a full end to end high quality run. Likewise, the costs are still out of reach for the average person but they are decreasing (exponentially!) and we will eventually have affordable technology, like a cell phone or AI, telling us about our DNA + RNA expression real-time.

Before we actually spend all this time and money on sequencing, what can we actually do with our genome?

The genome is not magic by itself- it is the reference layer. Once I have a VCF, I can run it through tools like VEP , ClinVar , gnomAD , PharmGKB (highly recommend), Gene Inspector , or Claude, and start asking:

This last part matters- the information produced is not yet diagnosis-level, and it is definitely not “edit yourself with CRISPR because an AI said so.” The near-term value is turning a static genome into something queryable, but the “edit yourself with CRISPR” will most likely follow. DNA is the stable reference, RNA is the current state, and we will eventually integrate all biosensor data into one ‘model’ of yourself.