Protein restriction may trigger body-wide program linked to longer life
A new perspective from LSU's Pennington Biomedical Research Center proposes a new way of understanding how dietary protein restriction may promote healthy aging and extend lifespan: through a coordinated physiological response that connects cellular nutrient sensing with hormones, the brain and changes throughout the body.
by Pennington Biomedical Research Center
edited by Gaby Clark , reviewed by Robert Egan
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"Protein restriction and the hallmarks of aging: A coordinated physiological adaptive response?"—authored by Dr. Chris Morrison, Dr. Sora Kim and Dr. Sangho Yu of Pennington Biomedical—was recently published in the journal Cell Metabolism . The authors argue that the diverse effects of protein restriction, including changes in metabolism, glucose regulation, energy expenditure, growth and food preferences, should be viewed as interconnected components of a broader response to protein scarcity rather than as isolated biological pathways.
The perspective provides a framework for investigating how the body's response to protein scarcity may influence healthy aging and longevity and whether that response can be measured or ultimately targeted to improve health across the lifespan.