Researchers swap in human brain cells for a mouse's cortex
In recent years, there has been a lot of excitement about the potential for studying human diseases in what are called "organoids." These small patches of tissue, formed using stem cells, appear to produce many of the same cell types and at least some of the structures normally formed in actual organs, and thus can provide a better model for diseases that rely on the sometimes complex interactions among multiple specialized cell types that are a feature of the human body. But even the most sophisticated organoids lack a lot of the features of a real human body. This is especially true for brain organoids, which don't form any of the connections with specialized brain structures needed to behave "normally." On Wednesday, a research group at Stanford University described a possible way to study brain organoids in a somewhat more natural context: They genetically wiped out a large portion of the mouse brain and replaced it with human brain organoid cells. The replacements Organoids, because they adopt a three-dimensional tissue structure and consist of various specialized cells, provide a much better model for an intact tissue than simply having a bunch of disassociated cells lying flat on a culture dish. But they still have a lot of limitations—they're not hooked up to a circulatory system that allows the liver to process chemicals the organoid produces and don't have immune cells moving through them, to give just a couple of examples. Read full article Comments
The results are only a slight improvement over missing the entire brain structure.
This is especially limiting for studies of the brain, where any specialized structures are surrounded by structures that may exchange information with them, and often have long-range connections. An organoid is better than nothing, but it may not be a lot better if you’re interested in a disease that impacts communication among multiple brain regions.
One alternative has been to implant human neural stem cells into the brains of another species, where they’ll generally integrate into the nervous system and actively signal to their neighbors. But, given that those human cells are surrounded by the normally functioning neurons of their hosts, it’s not clear how much you can learn from this.
